How to prevent dementia in the elderly through diet supplementation?

To prevent dementia in the elderly, it is a good way to prevent dementia through diet supplementation, but how to eat? To prevent dementia, I want to adopt a Mediterranean diet. Supplementing fish EPA and vitamins are all good nutrients, but is it okay to use nutrients that are helpful for preventing dementia? Between diet and body? There is a lot of health knowledge, and there are more things to know:

Prevent dementia in the elderly through diet supplementation

A single ingredient is useless, compound and multiple nutrients are effective

There are many nutrients and ingredients that are considered to prevent dementia, but none of them are the key ingredients that “just eat to prevent dementia .” Nutrients have complex interactions in the human body, and the mechanism is still an unknown black box.

Vitamin B12 is considered to be a nutrient closely related to dementia , but there is almost no extreme deficiency of vitaminB12 in thehuman body. Some people may have insufficient vitamin B12 due to genetic factors or stomach removal. These people can treat symptoms by supplementing vitamin B12, but it is still unknown whether other people can prevent dementia by supplementing vitamin B12 alone.

Vitamin B12 is absorbed when combined with factors that easily absorb vitamin B12.

After vitamin B12 is combined with the protein in the food and enters the stomach, the protein will be broken down by an enzyme called pepsin, and the free vitamin B12 is combined with cobalamin protein (a protein in saliva) to avoid vitamin B12 in The stomach full of strong acid is absorbed.

The vitamin B12 conjugate closely bound to the cobalamin protein travels from the stomach to the duodenum, where the cobalamin protein is decomposed by pancreatic juice, and the free vitamin B12 is related to the gastric intrinsic factor secreted by the stomach (glycoprotein produced by parietal cells). ) Combined and absorbed in the small intestine.

Like the above mechanism, vitamin B12 will not be directly absorbed, but will repeatedly combine with other substances, the path is very complicated. Therefore, in addition to vitamin B12, the role of other nutrients and digestive organs such as the stomach must also be considered.

Although EPA and DHA, which are rich in fish oil, are believed to prevent dementia , it is still unclear whether they can act alone or need to cooperate with other factors.

In the hypothesis, EPA and DHA can make the blood clear and flow smoothly, and because sufficient nutrients and oxygen are transported to the brain, it can prevent dementia.

After giving laboratory animals EPA and DHA, it was found that amyloid β in the brain, the cause of dementia, was reduced. But this hypothesis is only based on the saying that humans can also be effective, and we don’t know whether it is really effective for humans. Although we can measure EPA and DHA in blood, it is still unclear whether the experimental results are also applicable to humans.

Since humans cannot accept the same experiments as animals, epidemiological investigations are needed to confirm whether the experimental results are equally applicable to humans. However, it is still difficult to determine the relationship between dementia and EPA and DHA.

It is not easy to investigate the correlation between food and dementia. Because it takes a lot of time to trace the onset of dementia. If it is not possible to track it continuously for twenty to twenty-five years, it is impossible to know whether the research subject will suffer from dementia. At least ten years must be tracked. However, it is impossible for the research subjects to continue to eat foods that are uncertain whether they are effective for ten or twenty years . Therefore, it is very difficult to prove the connection between food and dementia.

Jin Xianjing, the head of the research department of the research institute, worked with the manufacturer to study the mold effect of Camembert cheese.

The mold of Camembert cheese secretes BDNF, a neurotrophic factor. Compared with other cheeses, only the mold in Camembert cheese can rapidly increase the secretion of BDNF, which has been confirmed in animal experiments.

Science has proven that the secretion of BDNF can promote nerve regeneration. But it is still unclear whether it is effective for dementia. Although “the increase in BDNF seems to improve dementia” is a hypothesis, there is still a big gap between the increase in BDNF and the improvement of dementia, and it is very difficult to use people as experimental subjects.

It can be asserted that only a balanced diet ( containing nutrients with various effects ) is important. The elderly in Japan have a tendency to “eat less and coarse food”. Eating less may not be able to get a variety of nutrients. Among the three major nutrients, the lack of protein and lipid intake of the elderly is obvious .

In our epidemiological studies, it has been confirmed that the lower the values ​​of albumin and total cholesterol of the silver-haired group, the more likely it is to deteriorate physical and cognitive functions. Therefore, to prevent dementia, countermeasures to prevent undernutrition should be included as one of the solutions.

A well-balanced diet is closely related to the health of the body (prevention of old age and frailty) and mental health (prevention of dementia).

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